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Chemical Structure : GNE-6640
CAS No.: 2009273-67-8
Catalog No.: PC-60012Not For Human Use, Lab Use Only.
GNE-6640 (GNE6640) is a potent, selective and non-covalent USP7 inhibitor with IC50 of 0.75 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-6640 (GNE6640) is a potent, selective and non-covalent USP7 inhibitor with IC50 of 0.75 uM.
GNE-6640 dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
GNE-6640 promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.
GNE-6640 decreased viability of 108 cancer cell lines with IC50 <10 uM.
| M.Wt | 330.391 | |
| Formula | C20H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[2-Amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridyl]phenol |
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1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.
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