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Chemical Structure : GNE-6776
CAS No.: 2009273-71-4
Catalog No.: PC-60089Not For Human Use, Lab Use Only.
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
GNE-6776 dislpalys selectivity over USP47 and USP5 (>200 uM).
GNE-6776 promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents.
GNE-6776 promotes on-target pathway modulation in human xenografts.
| M.Wt | 348.406 | |
| Formula | C20H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-[6-Amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2carboxamide |
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1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.
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