GNE-886 |CAS:2101957-05-3 Probechem Biochemicals

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Chemical Structure : GNE-886

GNE-886 (GNE886)

Catalog No.: PC-62550Not For Human Use, Lab Use Only.

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM.
GNE-886 shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1).
GNE-886 has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.

Physicochemical Properties

M.Wt	498.587
Formula	C28H30N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

References

1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741.

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GNE-886 (GNE886)

Biological Activity

Physicochemical Properties

References

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