GNE-955 |CAS:1527523-39-2 Probechem Biochemicals

Chemical Structure : GNE-955

GNE-955 (GNE955)

Catalog No.: PC-63140Not For Human Use, Lab Use Only.

GNE-955 (GNE955) is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.

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Biological Activity

GNE-955 (GNE955) is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
GNE-955 shows only 3 kinases >80% inhibition (Pim-1, 100%; CLK1, 97%; Flt3, 82%) at 0.1 uM in a panel of 70 kinases.
GNE-955 shows excellent bioavailability in rat.

Physicochemical Properties

M.Wt	415.501
Formula	C23H25N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)piperidin-3-amine

References

1. Wang X, et al. J Med Chem. 2017 May 25;60(10):4458-4473.

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GNE-955 (GNE955)

Biological Activity

Physicochemical Properties

References

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