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GNF-Pf-5660

Chemical Structure : GNF-Pf-5660

CAS No.: 421572-88-5

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GNF-Pf-5660 (GNF-Pf 5660)

Catalog No.: PC-61006Not For Human Use, Lab Use Only.

GNF-Pf-5660 is an antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GNF-Pf-5660 is an antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites.
    The digestive vacuole membrane-spanning transporter PfMDR1 is a determinant of parasite resistance to GNF-Pf-5660.

    Physicochemical Properties

    M.Wt 481.973
    Formula C27H28ClNO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

    References

    1. Vanaerschot M, et al. Nat Microbiol. 2017 Oct;2(10):1403-1414.

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