Catalog No.: PC-60315Not For Human Use, Lab Use Only.
GNF6702 (GNF 6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM.
GNF6702 (GNF 6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM.
GNF6702 displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM).
GNF6702 does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice.
GNF6702 clears parasites in mouse models of kinetoplastid infections.
