Chemical Structure : GPR101 agonist AA-14
CAS No.:
723740-38-3
GPR101 agonist AA-14
Catalog No.: PC-21343Not For Human Use, Lab Use Only.
GPR101 agonist AA-14 is a specific small molecule agonist of GPR101 with EC50 of 0.37 uM, 0.88 uM and 2.14 uM in activating Gs, Gq or β-arrestin2 assays respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GPR101 agonist AA-14 is a specific small molecule agonist of GPR101 with EC50 of 0.37 uM, 0.88 uM and 2.14 uM in activating Gs, Gq or β-arrestin2 assays respectively.
AA-14 selectively activated the Gs and Gq pathways downstream of GPR101, but not in HEK293 cells expressing any of the other tested receptors.
AA-14 partially restores the functions of GH/IGF-1 axis.
AA-14 (0.1 mg/kg per day) exerts rejuvenating effects through activating GPR101 in 8-week-old mic, which are abrogated in Gpr101-deficient mice.
AA-14 stimulates hormone synthesis in the pituitary of aged mice.
GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis.
Physicochemical Properties
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M.Wt
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311.33
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Formula
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C14H12F3N3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-methylpyridin-2-yl)-3-(3-(trifluoromethyl)phenyl)thiourea
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References
1. Yang Z, et al. Nat Chem Biol. 2023 Nov 9. doi: 10.1038/s41589-023-01456-6.
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