GPR52 agonist R-185

Chemical Structure : GPR52 agonist R-185

Catalog No.: PC-26922Not For Human Use, Lab Use Only.

GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice.

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Biological Activity

GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice.

Physicochemical Properties

M.Wt	461.42
Formula	C22H19F4N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(3-fluoro-5-(trifluoromethyl)phenoxy)piperidin-1-yl)-N-(pyridin-4-yl)pyrazine-2-carboxamide

References

1. Haoran Li, et al. J Med Chem. 2026 May 27. doi: 10.1021/acs.jmedchem.6c00686.

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