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GPRP acetate

Chemical Structure : GPRP acetate

CAS No.: 157009-81-9

GPRP acetate (Gly-Pro-Arg-Pro acetate, Pefabloc FG)

Catalog No.: PC-47483Not For Human Use, Lab Use Only.

GPRP acetate (Pefabloc FG) is a peptide corresponding partly to the amino terminus of the Aα chain and Bβ chain of fibrin, inhibits the spontaneous polymerization of fibrin monomers.

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Biological Activity

GPRP acetate (Pefabloc FG) is a peptide corresponding partly to the amino terminus of the Aα chain and Bβ chain of fibrin, inhibits the spontaneous polymerization of fibrin monomers.
GPRP acetate also inhibits ADP-induced platelet aggregation with IC50 of 3 mM.
GPRP acetate binds to the fibrinogen D domain, and inhibits the ability of fibrinogen to bind to the platelet membrane glycoprotein GPIIb/IIIa.

Physicochemical Properties

M.Wt 485.5346
Formula C20H35N7O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in H2O

Chemical Name/SMILES

L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1)

References

1. Laudano AP, et al. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3085-9.

2. Plow EF, et al. Proc Natl Acad Sci U S A. 1982 Jun;79(12):3711-5.

3. Adelman B, et al. Circ Res. 1990 Oct;67(4):941-7.

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