GQ352 | Gαq/11 inhibitor | Probechem Biochemicals

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Chemical Structure : GQ352

GQ352 (GQ-352)

Catalog No.: PC-47039Not For Human Use, Lab Use Only.

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.
GQ352 inhibits uveal melanoma (UM) tumorigenesis by suppressing Gαq/11 downstream ERK phosphorylation and YAP dephosphorylation.

Physicochemical Properties

M.Wt	462.682
Formula	C29H42N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-2-amino-1-((S)-8-(cyclohexylmethyl)-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-3-methylpentan-1-one

References

1. Jun-Jie Deng, et al. Eur J Med Chem. 2022 Jun 11;239:114520.

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GQ352 (GQ-352)

Biological Activity

Physicochemical Properties

References

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