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GQ352

Chemical Structure : GQ352

CAS No.:

GQ352

Catalog No.: PC-47039Not For Human Use, Lab Use Only.

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.
GQ352 inhibits uveal melanoma (UM) tumorigenesis by suppressing Gαq/11 downstream ERK phosphorylation and YAP dephosphorylation.

Physicochemical Properties

M.Wt 462.682
Formula C29H42N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Jun-Jie Deng, et al. Eur J Med Chem. 2022 Jun 11;239:114520.

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