Catalog No.: PC-23911Not For Human Use, Lab Use Only.
GRK5-IN-2 (Compound 707)is a potent, selective G-protein-coupled receptor kinase 5 (GRK5) inhibitor with IC50 of 49.7 uM in luminescent ADP detection assay.
GRK5-IN-2 (Compound 707)is a potent, selective G-protein-coupled receptor kinase 5 (GRK5) inhibitor with IC50 of 49.7 uM in luminescent ADP detection assay. GRK5-IN-2 treatment significantly decreased TAG synthesis during 7 days of WT 3T3-L1 adipocyte differentiation in a dose-dependent manner. GRK5-IN-2 inhibitor treatment significantly decreased the rate of TAG, cholesteryl ester (CE), and phospholipid (PL), but not free cholesterol (FC), synthesis from [14C]-acetic acid in WT 3T3-L1 adipocyte.
1. Axel Ullrich, et al. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators. EP2818472A1.
2. Seramur ME, et al. Int J Obes (Lond). 2025 Jan 21. doi: 10.1038/s41366-025-01712-w.
