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Chemical Structure : GS-6201
CAS No.: 752222-83-6
Catalog No.: PC-20101Not For Human Use, Lab Use Only.
GS-6201 (CVT-6883, GS-6201) is a specific and selective A2B adenosine receptor antagonist with Ki of 22 nM, >50-fold selectivity over A3, A1 and A2A receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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GS-6201 (CVT-6883, GS-6201) is a specific and selective A2B adenosine receptor antagonist with Ki of 22 nM, >50-fold selectivity over A3, A1 and A2A receptors.
GS-6201 (0.4, 1.0, or 2.5 mg/kg i.p.) significantly attenuated aerosolized NECA elicited concentration-dependent increases in Penh.
GS-6201 (1 mg/kg i.p.) attenuated allergen challenge induced late allergic response in sensitized mice.
GS-6201 (4 mg/kg, i.p.) attenuated cardiac remodeling after acute myocardial infarction in the mouse.
| M.Wt | 446.43 | |
| Formula | C21H21F3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-ethyl-1-propyl-8-(1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl)-3,7-dihydropurine-2,6-dione |
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1. Toldo S, et al. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.
2. Mustafa SJ, et al. J Pharmacol Exp Ther. 2007 Mar;320(3):1246-51.
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