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Chemical Structure : GS-626510
Catalog No.: PC-70222Not For Human Use, Lab Use Only.
GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT.
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GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT; shows weak affinity for CREBBP and EP300 (Ki=170 and 220 nM); potently inhibits growth of RKO cells with IC50 of 33 nM, decreases MYC levels; TRIM33 is required for the ability of GS-626510 to maximally down-regulate MYC.
| M.Wt | 394.478 | |
| Formula | C25H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shi X, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
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