GSK-3β inhibitor 47

Chemical Structure : GSK-3β inhibitor 47

Catalog No.: PC-20114Not For Human Use, Lab Use Only.

GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.

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Biological Activity

GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.
GSK-3β inhibitor 47 significantly lowered levels of phosphorylated tau in triple-transgenic mouse Alzheimer's disease models.

Physicochemical Properties

M.Wt	414.47
Formula	C23H22N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide

References

1. Richard A. et al. J. Med. Chem. 2023

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