Chemical Structure : GSK-3β inhibitor G3I
CAS No.:
2025388-20-7
GSK-3β inhibitor G3I
Catalog No.: PC-25343Not For Human Use, Lab Use Only.
GSK-3β inhibitor G3I is a specific GSK-3β inhibitor, inhibits nitric oxide (NO) production in LPS-stimulated macrophages with IC50 of 3.65 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GSK-3β inhibitor G3I is a specific GSK-3β inhibitor, inhibits nitric oxide (NO) production in LPS-stimulated macrophages with IC50 of 3.65 uM.
G3I reduces total phosphorylation in macrophages and decreases the production of pro-inflammatory cytokines in LPS-stimulated macrophages.
G3I decreases the phosphorylation of NF-κB transcription factor acting as anti-inflammatory reagent。
G3I regulates macrophage polarization, markedly suppresses the expression of Arginase-1 (Arg-1), CD206, and CCL18, indicative of M2-like phenotype inhibition.
G3I improves the tumor cell cytotoxicity and phagocytosis efficacy of M1-like macrophages and reinforces tumoricidal activity in in vivo mouse model.
G3I enhances the tumoricidal activity of macrophages in vivo.
Physicochemical Properties
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M.Wt
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372.40
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Formula
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C22H17FN4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(3-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-(pyridin-4-ylmethyl)acrylamide
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References
1. Lee C, et al. Biomed Pharmacother. 2025 Aug 11;191:118448.
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