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Chemical Structure : GSK-690693
CAS No.: 937174-76-0
Catalog No.: PC-42484Not For Human Use, Lab Use Only.
GSK-690693 (GSK690693) is a potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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GSK-690693 (GSK690693) is a potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
GSK-690693 (GSK690693) also inhibits additional members of the AGC kinase family (PKA, PrkX, and PKC isozymes, IC50s<100 nM).
GSK-690693 (GSK690693) dose-dependently reduces the phosphorylation GSK3 beta, PRAS40 and Forkhead, inhibits proliferation and induces apoptosis in a subset of tumor cells.
GSK-690693 (GSK690693) exhibits significant antitumor activity in mice model.
| M.Wt | 425.4842 | |
| Formula | C21H27N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl- |
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1. Heerding DA, et al. J Med Chem. 2008 Sep 25;51(18):5663-79.
2. Rhodes N, et al. Cancer Res. 2008 Apr 1;68(7):2366-74.
3. Levy DS, et al. Blood. 2009 Feb 19;113(8):1723-9.
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