GSK023 | BET BD1 inhibitor | Probechem Biochemicals

Chemical Structure : GSK023

GSK023 (GSK-023, GSK 023)

Catalog No.: PC-21329Not For Human Use, Lab Use Only.

GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2.

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Biological Activity

GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2.
GSK023 decreases the levels of MCP-1, IL-8, IL-1, IL-10, M-CSF, and IL-6 in human primary T cells.

Physicochemical Properties

M.Wt	489.66
Formula	C29H39N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(1-((1-(1-Isopropylpiperidine-4-carbonyl)piperidin-3-yl)methyl)-1H-benzo [d]imidazole-2-yl)-1,3-dimethylpyridin-2(1H)-one

References

1. Bradley E, et al. J Med Chem. 2023 Nov 15. doi: 10.1021/acs.jmedchem.3c00906.

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GSK023 (GSK-023, GSK 023)

Biological Activity

Physicochemical Properties

References

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