Chemical Structure : GSK143
CAS No.:
1240390-27-5
GSK143
(GSK-143, GSK 143)
Catalog No. : PC-63376Not For Human Use, Lab Use Only.
GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6337601
Biological Activity
GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70.
Physicochemical Properties
M.Wt
342.396
Formula
C17H22N6O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)-4-(p-tolylamino)pyrimidine-5-carboxamide
References
1. Liddle J, et al. Bioorg Med Chem Lett
2. van Bree SH, et al. Gut
3. Salehi S, et al. PLoS One
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