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Chemical Structure : GSK143
Catalog No.: PC-63376Not For Human Use, Lab Use Only.
GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70.
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GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70.
GSK143 inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos cells with pIC50 of 7.1, and anti-IgM induced CD69 surface expression in primary B cells with pIC50 of 6.6.
GSK143 shows good efficacy in the rat Arthus model.
| M.Wt | 342.396 | |
| Formula | C17H22N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liddle J, et al. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94.
2. van Bree SH, et al. Gut. 2013 Nov;62(11):1581-90.
3. Salehi S, et al. PLoS One. 2017 Jan 20;12(1):e0163614.
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