Catalog No.: PC-60294Not For Human Use, Lab Use Only.
GSK2193874 (GSK 2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively.
GSK2193874 (GSK 2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively.
GSK2193874 shows high selectivity against TRPV1, TRPA1, TRPC3, TRPC6, TRPM8 (IC50>25 uM).
GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor which demonstrates ability to improve pulmonary functions in a number of heart failure models.
