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Chemical Structure : GSK2245035
CAS No.: 1207629-49-9
Catalog No.: PC-63385Not For Human Use, Lab Use Only.
GSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $438 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50.
GSK2245035 suppresses Th2 cytokine responses to allergens in human cell cultures, causes local upregulation of TLR7-mediated cytokines (IP-10) in vivo after intranasal administration at very low doses.
| M.Wt | 390.532 | |
| Formula | C20H34N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8H-purin-8-one |
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1. Biggadike K, et al. J Med Chem. 2016 Mar 10;59(5):1711-26.
2. Ellis AK, et al. Clin Exp Allergy. 2017 Sep;47(9):1193-1203.
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