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Chemical Structure : GSK2256294A
CAS No.: 1142090-23-0
Catalog No.: PC-45669Not For Human Use, Lab Use Only.
GSK2256294A is a potent, selective soluble epoxide hydrolase (sEH, EPHX2) inhibitor with IC50 of 27/61/189 pM for recombinant human/rat/mouse sEH, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK2256294A is a potent, selective soluble epoxide hydrolase (sEH, EPHX2) inhibitor with IC50 of 27/61/189 pM for recombinant human/rat/mouse sEH, respectively.
GSK2256294A exhibites potent cell-based activity, a concentration-dependent inhibition of the conversion of 14,15-EET to 14,15-DHET in human (IC50=6.83 nM), rat and mouse whole blood in vitro, and a dose-dependent increase in the LTX/LTX diol ratio in rats; orally active.
| M.Wt | 447.4568 | |
| Formula | C21H24F3N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)- |
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1. Podolin PL, et al. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31.
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