GSK2646264 |CAS:1398695-47-0 Probechem Biochemicals

Chemical Structure : GSK2646264

CAS No.: 1398695-47-0

GSK2646264 (GSK-2646264;GSK 2646264)

Catalog No.: PC-35689Not For Human Use, Lab Use Only.

GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B.

Packing	Price	Stock
2 mg	$398	In stock
5 mg	$598	In stock
10 mg	$898	In stock
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Biological Activity

GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B。
GSK2646264 inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos B cells with pIC50 of 6.7.

Physicochemical Properties

M.Wt	374.484
Formula	C24H26N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-methoxy-6-((4-methylpyridin-2-yl)methoxy)phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

References

1. Barker MD, et al. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-3462.

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GSK2646264 (GSK-2646264;GSK 2646264)

Biological Activity

Physicochemical Properties

References

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