GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively.
GSK 2833503A dispalys >100-fold selectivity over other calcium-permeable channels.
GSK 2833503A shows 100-fold greater potency for TRPC3 compared with Pyr3.
GSK 2833503A dose-dependent blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.
