Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Rev-ErbA-GSK2945
GSK2945

Chemical Structure : GSK2945

CAS No.: 1438071-12-5

Add to Favorites

GSK2945 (GSK-2945)

Catalog No.: PC-62690Not For Human Use, Lab Use Only.

GSK2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα.

Packing Price Stock Quantity
10 mg $198 In stock
25 mg $328 In stock
50 mg $548 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα.
GSK2945 inhibits LPS induction of IL-6 production and to upregulate expression of ABCA1 in human THP-1 cells.
GSK2945 demonstrates in vivo bioavailability and orally active.

Physicochemical Properties

M.Wt 421.336
Formula C20H18Cl2N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine

References

1. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.

2. Zhang T, et al. Drug Metab Dispos. 2018 Mar;46(3):248-258.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: