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Chemical Structure : GSK2945
CAS No.: 1438071-12-5
Catalog No.: PC-62690Not For Human Use, Lab Use Only.
GSK2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα.
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|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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GSK2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα.
GSK2945 inhibits LPS induction of IL-6 production and to upregulate expression of ABCA1 in human THP-1 cells.
GSK2945 demonstrates in vivo bioavailability and orally active.
| M.Wt | 421.336 | |
| Formula | C20H18Cl2N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine |
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1. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
2. Zhang T, et al. Drug Metab Dispos. 2018 Mar;46(3):248-258.
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