Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GSK2973980A
Catalog No.: PC-62635Not For Human Use, Lab Use Only.
GSK2973980A is a potent and selective DGAT1 inhibitor with IC50 of 3 nM, exhibits >2,900-fold selectivity over human DGAT2, ACAT1 and ACAT2 (IC50>10 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GSK2973980A is a potent and selective DGAT1 inhibitor with IC50 of 3 nM, exhibits >2,900-fold selectivity over human DGAT2, ACAT1 and ACAT2 (IC50>10 uM).
GSK2973980A exhibits IC50 value of 77 nM in the cell-based C2C12 assay, also has excellent cardiac ion channel profile with IC50 of >10 uM in the hERG, Nav1.5 and Cav1.2。
GSK2973980A demonstrates excellent DMPK profiles and in vivo efficacy in a postprandial lipid excursion model in mice.
| M.Wt | 534.443 | |
| Formula | C25H19F5N4O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Cheung M, et al. ACS Med Chem Lett. 2018 Jan 16;9(2):103-108.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
