Catalog No.: PC-60455Not For Human Use, Lab Use Only.
GSK2981278 (GSK-2981278) is a potent, highly selective RORγ antagonist that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM.
GSK2981278 (GSK-2981278) is a potent, highly selective RORγ antagonist that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM.
GSK2981278 shows no effects on RORα-dependent activation.
GSK2981278 robustly inhibits RORγ-mediated cytokine production at both the mRNA and protein level, inhibits RORγt-mediated transactivation; attenuates inflammation in mouse model of psoriasis.
