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GSK3004774

Chemical Structure : GSK3004774

CAS No.: 2138814-32-9

GSK3004774 (GSK 3004774;GSK-3004774)

Catalog No.: PC-35260Not For Human Use, Lab Use Only.

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.
GSK3004774 demonstrates low permeability and low portal drug concentrations and high luminal stability and high fecal drug recovery in vivo DMPK experiments.

Physicochemical Properties

M.Wt 528.697
Formula C32H40N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)benzamido)propyl)piperidine-4-carboxylic acid

References

1.  Sparks SM, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4673-4677. 

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