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GSK3357679

Chemical Structure : GSK3357679

CAS No.: 1802987-00-3

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GSK3357679 (GSK-3357679)

Catalog No.: PC-25956Not For Human Use, Lab Use Only.

GSK3357679 is a highly potent, selective and brain-penetrant LRRK2 inhibitor with IC50 of 20.0 nM in SHSY5Y cells measuring inhibition of pS935.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GSK3357679 is a highly potent, selective and brain-penetrant LRRK2 inhibitor with IC50 of 20.0 nM in SHSY5Y cells measuring inhibition of pS935.
GSK3357679 demonstrates favorable kinase selectivity and excellent in vitro and in vivo PK profiles in rats and dogs.
GSK3357679 is a useful new in vitro and in vivo tool molecule to investigate the role of LRRK2 in Parkinson's disease in cell and rodent models.

Physicochemical Properties

M.Wt 435.89
Formula C19H23ClFN7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-chloro-1-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine

References

1. Axten JM, et al. RSC Med Chem. 2025 Nov 17. doi: 10.1039/d5md00856e.

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