GSK3491943 | TRPV4 inhibitor | Probechem Biochemicals

Chemical Structure : GSK3491943

Catalog No.: PC-22742Not For Human Use, Lab Use Only.

GSK3491943 is a potent, selective TRPV4 inhibitor with IC50 of 3.2 nM (hTRPV4).

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Biological Activity

GSK3491943 is a potent, selective TRPV4 inhibitor with IC50 of 3.2 nM (hTRPV4).

M.Wt	491.35
Formula	C18H16Cl2N2O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Chloro-4-(((3R,4S)-4-((4-chlorophenyl)sulfonyl)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile

1. Joseph E Pero, et al. J Med Chem. 2018 Dec 27;61(24):11209-11220.

2. Carl A Brooks, et al. J Med Chem. 2019 Oct 24;62(20):9270-9280.