Catalog No.: PC-20276Not For Human Use, Lab Use Only.
GSK3787 (GSK 3787) is a potent, selective and irreversible antagonist of PPARdelta (PPARδ) with binding pIC50 of 6.6, without measurable affinity for hPPARα or hPPARγ.
GSK3787 (GSK 3787) is a potent, selective and irreversible antagonist of PPARdelta (PPARδ) with binding pIC50 of 6.6, without measurable affinity for hPPARα or hPPARγ.
GSK3787 shows equipotent species activity against the human and mouse receptor.
GSK3787 covalently modifies PPARδ Cys249 within the ligand binding pocket.
PPARδ antagonizes the induction of PPARδ-regulated target genes in skeletal muscle cells.
GSK3787 antagonizes GW0742-induced expression of Angptl4 in mouse fibroblasts, mouse keratinocytes, and human cancer cell lines.
