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Chemical Structure : GSK4112
CAS No.: 1216744-19-2
Catalog No.: PC-43929Not For Human Use, Lab Use Only.
GSK4112 (SR6452) is a potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assays.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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GSK4112 (SR6452) is a potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assays.
GSK4112 mediates the repression of Rev-erbα target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.
| M.Wt | 396.8883 | |
| Formula | C18H21ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester |
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2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.
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