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GSK467

Chemical Structure : GSK467

CAS No.: 1628332-52-4

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GSK467 (GSK-467, GSK 467)

Catalog No.: PC-62292Not For Human Use, Lab Use Only.

GSK467 (GSK-467) is a potent, selective KDM5B (JARID1B) inhibitor with Ki of 10 nM and IC50 of 26 nM.

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5 mg $138 In stock
10 mg $218 In stock
25 mg $378 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK467 (GSK-467) is a potent, selective KDM5B (JARID1B) inhibitor with Ki of 10 nM and IC50 of 26 nM.
GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members.
GSK-467 (GSK467) increases the rate of apoptosis in myeloma cells.

Physicochemical Properties

M.Wt 319.32
Formula C17H13N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one

References

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.

2. Westaway SM, et al. J Med Chem. 2016 Feb 25;59(4):1370-87.

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