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Chemical Structure : GSK598809
Catalog No.: PC-60743Not For Human Use, Lab Use Only.
GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9.
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GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors; significantly attenuates the expression of conditioned place preference (CPP) to nicotine and cocaine; potentiates the hemodynamic effects of cocaine in dogs, also increases mean arterial blood pressure and heart rate in vivo.
Other Indication
Phase 2 Clinical
| M.Wt | 481.514 | |
| Formula | C22H23F4N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Micheli F, et al. J Med Chem. 2010 Jan 14;53(1):374-91.
2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.
3. Dodds CM, et al. Appetite. 2012 Aug;59(1):27-33.
4. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.
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