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Chemical Structure : GSK618069
Catalog No.: PC-22502Not For Human Use, Lab Use Only.
GSK618069 is a potent, selective antagonist of relaxin family peptide receptor 2 (RXFP2) with IC50 of 0.4 uM in HEK-hRXFP2 cAMP assays, 200-fold reduced potency against rRXFP2.
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GSK618069 is a potent, selective antagonist of relaxin family peptide receptor 2 (RXFP2) with IC50 of 0.4 uM in HEK-hRXFP2 cAMP assays, 200-fold reduced potency against rRXFP2.
GSK618069 inhibits INSL3-stimulated CYP11B2 mRNA expression (IC50 = 2.8 µM) in adrenal cell assays.
GSK618069 reduces aldosterone and cortisol synthesis and release.
| M.Wt | 473.63 | |
| Formula | C27H35N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang SS, et al. Sci Rep. 2024 Jun 8;14(1):13209.
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