GSK618069 | FXRP2 antagonist | Probechem Biochemicals

Chemical Structure : GSK618069

GSK618069 (GSK-618069)

Catalog No.: PC-22502Not For Human Use, Lab Use Only.

GSK618069 is a potent, selective antagonist of relaxin family peptide receptor 2 (RXFP2) with IC50 of 0.4 uM in HEK-hRXFP2 cAMP assays, 200-fold reduced potency against rRXFP2.

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Biological Activity

GSK618069 is a potent, selective antagonist of relaxin family peptide receptor 2 (RXFP2) with IC50 of 0.4 uM in HEK-hRXFP2 cAMP assays, 200-fold reduced potency against rRXFP2.
GSK618069 inhibits INSL3-stimulated CYP11B2 mRNA expression (IC50 = 2.8 µM) in adrenal cell assays.
GSK618069 reduces aldosterone and cortisol synthesis and release.

Physicochemical Properties

M.Wt	473.63
Formula	C27H35N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopentyl-4-(1-(piperidin-4-yl)-2-(pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)piperazine-1-carboxamide

References

1. Zhang SS, et al. Sci Rep. 2024 Jun 8;14(1):13209.

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GSK618069 (GSK-618069)

Biological Activity

Physicochemical Properties

References

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