GSK805 | RORγt inhibitor | Probechem Biochemicals

Chemical Structure : GSK805

CAS No.: 1426802-50-7

GSK805 (GSK-805)

Catalog No.: PC-43201Not For Human Use, Lab Use Only.

GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$378	In stock
50 mg	$578	In stock
100 mg		Get quote

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Biological Activity

GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively。
GSK805 demonstrates excellent in vivo efficacy in EAE mice dose dependently.

Physicochemical Properties

M.Wt	532.3596
Formula	C23H18Cl2F3NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-

References

1. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92.

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GSK805 (GSK-805)

Biological Activity

Physicochemical Properties

References

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