GSK898 | KMO inhibitor | Probechem Biochemicals

Chemical Structure : GSK898

GSK898 (GSK-898)

Catalog No.: PC-20933Not For Human Use, Lab Use Only.

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.

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Biological Activity

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.
GSK898 shows no inhibitory effects on the other enzymes in the tryptophan metabolism pathway (IDO, TDO, KATI/II, kynureninase).
GSK898 rescues the phenotype, reducing 3-hydroxykynurenine and protecting against critical illness and death.

Physicochemical Properties

M.Wt	360.79
Formula	C18H17ClN2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)CCC1=NOC2=CC(O[C@@H](C3=NC=C(C)C=C3)C)=C(Cl)C=C12

References

1. Alastair J Hayes, et al. Cell Rep. 2023 Jul 19;42(8):112763.

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GSK898 (GSK-898)

Biological Activity

Physicochemical Properties

References

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