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Chemical Structure : GSK923295
CAS No.: 1088965-37-0
Catalog No.: PC-42514Not For Human Use, Lab Use Only.
GSK-923295 (GSK923295) is the first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK-923295 (GSK923295) is the first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM.
GSK-923295 shows excellent selectivity against a panel of mitotic human kinesins.
GSK-923295 exhibits inhibition of cell proliferation in a broad panel of human cancer cell lines and induces mitotic arrest leading to apoptosis and cell death (SKOV-3 IC50=22 nM; Colo205 IC50=22 nM).
GSK-923295 induces tumor regressions in vivo.
| M.Wt | 592.1282 | |
| Formula | C32H38ClN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 3-chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)- |
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1. Wood KW, et al. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44.
2. Qian X, et al. ACS Med Chem Lett. 2010 Jan 19;1(1):30-4.
3. Balamuth NJ, et al. Cancer Res. 2010 Apr 1;70(7):2749-58.
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