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Chemical Structure : GTC365 hydrochloride
Catalog No.: PC-63058Not For Human Use, Lab Use Only.
GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters.
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GTC-365 (NSC 177365) hydrochloride is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters.
GTC-365 acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression.
GTC-365 binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM).
| M.Wt | 530 | |
| Formula | C23H24ClN7O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kang HJ, et al. J. Am. Chem. Soc., 2016, 138 (41), pp 13673–13692
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