GW0742 is a potent, selective small molecule agonist of PPARδ with EC50 of 1.0 nM, 1000-fold selectivity over the other human PPAR subtypes. GW0742 can restore partly the expression of certain key genes of fatty acid oxidation in mouse adult cardiomyocytes isolated from PPARalpha knockout mice. GW0742 significantly reduces cell death during a 12-hr exposure to low-KCl media in rat cultured cerebellar granule neurons.
