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Chemical Structure : GW0742
CAS No.: 317318-84-6
Catalog No.: PC-22387Not For Human Use, Lab Use Only.
GW0742 is a potent, selective small molecule agonist of PPARδ with EC50 of 1.0 nM, 1000-fold selectivity over the other human PPAR subtypes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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GW0742 is a potent, selective small molecule agonist of PPARδ with EC50 of 1.0 nM, 1000-fold selectivity over the other human PPAR subtypes.
GW0742 can restore partly the expression of certain key genes of fatty acid oxidation in mouse adult cardiomyocytes isolated from PPARalpha knockout mice.
GW0742 significantly reduces cell death during a 12-hr exposure to low-KCl media in rat cultured cerebellar granule neurons.
| M.Wt | 471.48 | |
| Formula | C21H17F4NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid |
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1. Sznaidman ML, et al. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21.
2. Cheng L, et al. Biochem Biophys Res Commun. 2004 Jan 9;313(2):277-86.
3. Smith SA, et al. J Neurosci Res. 2004 Jul 15;77(2):240-9.
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