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Chemical Structure : GW280264X
CAS No.: 866924-39-2
Catalog No.: PC-73156Not For Human Use, Lab Use Only.
GW280264X is a potent, dual ADAM10/TACE (ADAM17) metalloproteinases inhibitor with IC50 of 8.0 nM and 11.5 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $158 | In stock | |
| 5 mg | $358 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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GW280264X is a potent, dual ADAM10/TACE (ADAM17) metalloproteinases inhibitor with IC50 of 8.0 nM and 11.5 nM, respectively.
GW280264X is an effective inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage in CX3CL1-expressing ECV-304 cells.
GW280264X blocked IL-6-induced proliferation and ERK1/2 phosphorylation with same potency as GM6001 in non-transformed prostate epithelial cells.
GW280264X enhances platinum efficiency in ovarian cancer.
| M.Wt | 575.72 | |
| Formula | C28H41N5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzyl ((S)-5-((2R,3S)-3-(N-hydroxyformamido)-2-isobutylhexanamido)-6-oxo-6-(thiazol-2-ylamino)hexyl)carbamate |
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1. Budagian V, et al. J Biol Chem. 2004 Sep 24;279(39):40368-75.
2. Hundhausen C, et al. Blood. 2003 Aug 15;102(4):1186-95.
3. Rabie T, et al. J Biol Chem. 2005 Apr 15;280(15):14462-8.
4. Bourd-Boittin K, et al. J Cell Mol Med. 2009 Aug;13(8A):1526-35.
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