GW280264X is a potent, dual ADAM10/TACE (ADAM17) metalloproteinases inhibitor with IC50 of 8.0 nM and 11.5 nM, respectively.
GW280264X is an effective inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage in CX3CL1-expressing ECV-304 cells.
GW280264X blocked IL-6-induced proliferation and ERK1/2 phosphorylation with same potency as GM6001 in non-transformed prostate epithelial cells.
GW280264X enhances platinum efficiency in ovarian cancer.
