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GW405833

Chemical Structure : GW405833

CAS No.: 180002-83-9

GW405833 (L768242)

Catalog No.: PC-24076Not For Human Use, Lab Use Only.

GW405833 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW405833 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
GW405833 causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM.
GW405833 elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.

Physicochemical Properties

M.Wt 447.36
Formula C23H24Cl2N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone

References

1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.

2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.

3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.

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