Chemical Structure : GW4869
CAS No.:
6823-69-4
GW4869
(GW-4869, GW 4869)
Catalog No. : PC-45623Not For Human Use, Lab Use Only.
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4562301
Biological Activity
GW4869 (GW-4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.
Physicochemical Properties
M.Wt
577.5
Formula
C30H28N6O2 · 2HCl
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 0.044 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES
2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2)
References
1. Luberto C, et al. J Biol Chem.
2. Marchesini N, et al. J Biol Chem.
3. Airola MV, et al. Proc Natl Acad Sci U S A.
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