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GW4869

Chemical Structure : GW4869

CAS No.: 6823-69-4

GW4869 (GW-4869, GW 4869)

Catalog No.: PC-45623Not For Human Use, Lab Use Only.

GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW4869 (GW-4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.
GW4869 does not inhibit acid SMase (>150 uM).
GW4869 partially inhibits TNF-induced sphingomyelin (SM) hydrolysis at 10 uM.

Physicochemical Properties

M.Wt 577.5
Formula C30H28N6O2 · 2HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 0.044 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2)

References

1. Luberto C, et al. J Biol Chem. 2002 Oct 25;277(43):41128-39.

2. Marchesini N, et al. J Biol Chem. 2003 Apr 18;278(16):13775-83.

3. Airola MV, et al. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558.

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