 
                Chemical Structure : GW 501516
CAS No.: 317318-70-0
Catalog No.: PC-42713Not For Human Use, Lab Use Only.
GW 501516 (GW516) is a potent and subtype-selective PPARδ agonist with Ki of 1.1 nM in human PPARδ binding assay.
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	GW 501516 (GW516) is a potent and subtype-selective PPARδ agonist with Ki of 1.1 nM in human PPARδ binding assay.
	GW 501516 displays >1,000-fold selectivity over other PPAR subtypes.
	GW 501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux in macrophages, fibroblasts, and intestinal cells.
| M.Wt | 453.4977 | |
| Formula | C21H18F3NO3S2 | |
| Appearance | Solid | |
| Storage | 
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| Solubility | 10 mM in DMSO | |
| Chemical Name/SMILES | Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]- | |
1. Oliver WR Jr, et al. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11.
2. Sznaidman ML, et al. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21.
3. Tanaka T, et al. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9.

 
                 
                 
                 
                 
                 
                 
                 
                 
            
            
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