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GW 501516

Chemical Structure : GW 501516

CAS No.: 317318-70-0

GW 501516 (GW 1516;GSK-516;GW-501516)

Catalog No.: PC-42713Not For Human Use, Lab Use Only.

GW 501516 (GW516) is a potent and subtype-selective PPARδ agonist with Ki of 1.1 nM in human PPARδ binding assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW 501516 (GW516) is a potent and subtype-selective PPARδ agonist with Ki of 1.1 nM in human PPARδ binding assay.
GW 501516 displays >1,000-fold selectivity over other PPAR subtypes.
GW 501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux in macrophages, fibroblasts, and intestinal cells.

Physicochemical Properties

M.Wt 453.4977
Formula C21H18F3NO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-

References

1. Oliver WR Jr, et al. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11.

2. Sznaidman ML, et al. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21.

3. Tanaka T, et al. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9.

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