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Chemical Structure : GW 501516
CAS No.: 317318-70-0
Catalog No.: PC-42713Not For Human Use, Lab Use Only.
A potent and subtype-selective PPARδ agonist with Ki of 1.1 nM in human PPARδ binding assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $62.4 | In stock | |
| 50 mg | $152 | In stock | |
| 100 mg | $208 | In stock |
Bulk size, bulk discount!
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A potent and subtype-selective PPARδ agonist with Ki of 1.1 nM in human PPARδ binding assay; displays >1,000-fold selectivity over other PPAR subtypes; increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux in macrophages, fibroblasts, and intestinal cells.
Dyslipidemia
Phase 2 Discontinued
| M.Wt | 453.4977 | |
| Formula | C21H18F3NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]- |
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1. Oliver WR Jr, et al. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11.
2. Sznaidman ML, et al. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21.
3. Tanaka T, et al. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9.
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