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GW6471

Chemical Structure : GW6471

CAS No.: 880635-03-0

GW6471 (GW-6471, GW 6471)

Catalog No.: PC-62872Not For Human Use, Lab Use Only.

GW6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.

Physicochemical Properties

M.Wt 619.685
Formula C35H36F3N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

References

1. Müller MQ, et al. J Med Chem. 2009 May 14;52(9):2875-9.

2. Xu HE, et al. Nature. 2002 Feb 14;415(6873):813-7.

3. Muoio DM, et al. J Biol Chem. 2002 Jul 19;277(29):26089-97.

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