Chemical Structure : GW6471
CAS No.: 880635-03-0
Catalog No.: PC-62872Not For Human Use, Lab Use Only.
GW6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
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GW6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
M.Wt | 619.685 | |
Formula | C35H36F3N3O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide |
1. Müller MQ, et al. J Med Chem. 2009 May 14;52(9):2875-9.
2. Xu HE, et al. Nature. 2002 Feb 14;415(6873):813-7.
3. Muoio DM, et al. J Biol Chem. 2002 Jul 19;277(29):26089-97.
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