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GW 841819X

Chemical Structure : GW 841819X

CAS No.: 146135-18-4

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GW 841819X (GW841819X)

Catalog No.: PC-62317Not For Human Use, Lab Use Only.

GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain that displays activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain that displays activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia.

    Physicochemical Properties

    M.Wt 487.94
    Formula C26H22ClN5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-benzyl (6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

    References

    1. Chung CW, et al. J Med Chem. 2011 Jun 9;54(11):3827-38.

    2. Baud MG, et al. Science. 2014 Oct 31;346(6209):638-41.

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