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GWJ-A-23

Chemical Structure : GWJ-A-23

CAS No.: 1351930-95-4

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GWJ-A-23 (GWJ-23;GWJ23)

Catalog No.: PC-60640Not For Human Use, Lab Use Only.

GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound。
    GWJ-A-23 reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels。
    GWJ-A-23 attenuates the pathogenesis of pulmonary fibrosis in vivo.

    Physicochemical Properties

    M.Wt 385.14
    Formula C17H28NO4P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(decanoylamino)benzyl]phosphonic acid

    References

    1. Jiang G, et al. Bioorg Med Chem Lett. 2011 Sep 1;21(17):5098-101.

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