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Chemical Structure : GWJ-A-23
Catalog No.: PC-60640Not For Human Use, Lab Use Only.
GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound.
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GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound。
GWJ-A-23 reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels。
GWJ-A-23 attenuates the pathogenesis of pulmonary fibrosis in vivo.
| M.Wt | 385.14 | |
| Formula | C17H28NO4P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiang G, et al. Bioorg Med Chem Lett. 2011 Sep 1;21(17):5098-101.
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