GZ667161 | Glucosylceramide synthase inhibitor

Chemical Structure : GZ667161

GZ667161 (Genz-667161, Genz667161)

Catalog No.: PC-22860Not For Human Use, Lab Use Only.

GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS), alleviates aberrations in synucleinopathy models.

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Biological Activity

GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS), alleviates aberrations in synucleinopathy models.

Physicochemical Properties

M.Wt	382.48
Formula	C23H27FN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	quinuclidin-3-yl (2-(4'-fluoro-[1,1'-biphenyl]-3-yl)propan-2-yl)carbamate

References

1. Sardi SP, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2699-2704.

2. Cheong A, et al. Commun Biol. 2024 Aug 2;7(1):932.

3. Cabrera-Salazar MA, et al. PLoS One. 2012;7(8):e43310.

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GZ667161 (Genz-667161, Genz667161)

Biological Activity

Physicochemical Properties

References

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