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GZ667161

Chemical Structure : GZ667161

CAS No.: 1401090-10-5

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GZ667161 (Genz-667161, Genz667161)

Catalog No.: PC-22860Not For Human Use, Lab Use Only.

GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS), alleviates aberrations in synucleinopathy models.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS), alleviates aberrations in synucleinopathy models.

Physicochemical Properties

M.Wt 382.48
Formula C23H27FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

quinuclidin-3-yl (2-(4'-fluoro-[1,1'-biphenyl]-3-yl)propan-2-yl)carbamate

References

1. Sardi SP, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2699-2704.

2. Cheong A, et al. Commun Biol. 2024 Aug 2;7(1):932.

3. Cabrera-Salazar MA, et al. PLoS One. 2012;7(8):e43310.

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