Chemical Structure : GZNL-P36
CAS No.:
GZNL-P36
Catalog No.: PC-23545Not For Human Use, Lab Use Only.
GZNL-P36 is a potent, selective and orally bioavailable SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 6.45 nM, ITC Kd value of 24.6 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GZNL-P36 is a potent, selective and orally bioavailable SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 6.45 nM, ITC Kd value of 24.6 nM.
GZNL-P36 dose-dependently protects cells from death with 50% effective concentration (EC50) values for wild type (WT), Omicron BA.5 and XBB.1 is 111.0 nM, 306.2 nM and 58.2 nM, respectively.
GZNL-P36 possesses similar effective anti-viral activity for SARS-CoV-2 and its variants, compared with S-217622 (Ensitrelvir).
GZNL-P36 also exhibits anti-viral activity for the other coronaviruses, such as HCoV-NL63 (EC50: 81.6 nM) and HCoV-229E (EC50: 2.66 μM).
Oral administration of the GZNL-P36 results in significantly improved survival and notable reductions in lung viral loads and lesions in SARS-CoV-2 infection mouse model, consistent with RNA-seq data analysis.
Physicochemical Properties
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M.Wt
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466.59
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Formula
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C29H30N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-methyl-N-(1-(1-methyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)cyclopropyl)-5-(6-methyl-3,6-diazabicyclo[3.1.1]heptan-3-yl)benzamide
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References
1. Lu Y, et al. Nat Commun. 2024 Nov 23;15(1):10169.
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