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Galidesivir hydrochloride

Chemical Structure : Galidesivir hydrochloride

CAS No.: 222631-44-9

Galidesivir hydrochloride (BCX4430 hydrochloride, BCX-4430)

Catalog No.: PC-45502Not For Human Use, Lab Use Only.

Galidesivir hydrochloride (BCX4430) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator, inhibits MERS-CoV, SARS-CoV and SARS-CoV-2.

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Biological Activity

Galidesivir hydrochloride (BCX4430) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator, inhibits MERS-CoV, SARS-CoV and SARS-CoV-2.
Galidesivir (BCX4430) exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).

Physicochemical Properties

M.Wt 301.7294
Formula C11H16ClN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 41 mg/mL

Chemical Name/SMILES

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:1), (2S,3S,4R,5R)-

References

1. Warren TK, et al. Nature. 2014 Apr 17;508(7496):402-5.

2. Julander JG, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14.

3. Julander JG, et al. Antiviral Res. 2017 Jan;137:14-22.

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