Chemical Structure : Galidesivir hydrochloride
CAS No.: 222631-44-9
Catalog No.: PC-45502Not For Human Use, Lab Use Only.
Galidesivir hydrochloride (BCX4430) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator, inhibits MERS-CoV, SARS-CoV and SARS-CoV-2.
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Galidesivir hydrochloride (BCX4430) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator, inhibits MERS-CoV, SARS-CoV and SARS-CoV-2.
Galidesivir (BCX4430) exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).
M.Wt | 301.7294 | |
Formula | C11H16ClN5O3 | |
Appearance | Solid | |
Storage |
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Solubility |
H2O: ≥ 41 mg/mL |
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Chemical Name/SMILES |
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:1), (2S,3S,4R,5R)- |
1. Warren TK, et al. Nature. 2014 Apr 17;508(7496):402-5.
2. Julander JG, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14.
3. Julander JG, et al. Antiviral Res. 2017 Jan;137:14-22.
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