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Galvestine-1

Chemical Structure : Galvestine-1

CAS No.: 1087311-82-7

Galvestine-1 (Galvestine 1)

Catalog No.: PC-62193Not For Human Use, Lab Use Only.

Galvestine-1 is a small molecule MGDG (monogalactosyldiacylglycerol) synthase inhibitor with IC50 of 10 uM by competing with diacylglycerol binding.

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    Biological Activity

    Galvestine-1 is a small molecule MGDG (monogalactosyldiacylglycerol) synthase inhibitor with IC50 of 10 uM by competing with diacylglycerol binding.
    Galvestine-1 shows effect of root uptake, circulation in the xylem and mesophyll, inhibition of MGDs in vivo causing a reduction of MGDG content and impairment of chloroplast development in Arabidopsis thaliana.
    Galvestine-1 is a unique tool to study lipid homeostasis in plants.

    Physicochemical Properties

    M.Wt 498.627
    Formula C30H34N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    [(2S)-2-(dibenzylamino)propyl] 4-(2-oxo-3H-benzimidazol-1-yl)piperidine-1-carboxylate

    References

    1. Botté CY, et al. Nat Chem Biol. 2011 Sep 25;7(11):834-42.

    2. Boudière L, et al. Mol Biosyst. 2012 Aug;8(8):2023-35, 2014.

    3. Botella C, et al. Plant Physiol. 2016 Mar;170(3):1300-14.

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